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Acinar cell carcinoma of the pancreas, also acinar cell carcinoma, is a rare malignant exocrine tumour of the pancreas. It represents 5% of all exocrine tumours of the pancreas, making it the second most common type of pancreatic cancer. [1] It is abbreviated ACC. It typically has a guarded prognosis.
Exocrine pancreatic insufficiency (EPI) is the inability to properly digest food due to a lack or reduction of digestive enzymes made by the pancreas.EPI can occur in humans and is prevalent in many conditions [1] such as cystic fibrosis, [2] Shwachman–Diamond syndrome, [3] different types of pancreatitis, [4] multiple types of diabetes mellitus (Type 1 and Type 2 diabetes), [5] advanced ...
These tumors, which resemble serous acinar cells, vary in their behavior from locally aggressive to blatantly malignant. It can also appear in the breast. The pancreatic form of acinic cell carcinoma is a rare subtype of exocrine pancreatic cancer. Exocrine pancreatic cancers are the most common form of pancreatic cancer when compared to ...
An exocrine pancreas cell is a pancreatic cell that produces enzymes that are secreted into the small intestine. These enzymes help digest food by releasing enzymes as it passes through the gastrointestinal tract. These include acinar cells, which secrete bicarbonate solution and mucin
Acinar cells are stimulated by cholecystokinin (CCK), which is a hormone/neurotransmitter produced by the intestinal cells (I cells) in the duodenum. CCK stimulates production of the pancreatic zymogens. Pancreatic juice, composed of the secretions of both ductal and acinar cells, contains the following digestive enzymes: [11]
The exocrine pancreas is one of two compartments that include digestive-acting acinar cells and duct cells.They represent an extension of the intercalated duct into each pancreatic acinus. [1] These cells are commonly known as duct cells , and secrete an aqueous bicarbonate solution under stimulation by the hormone secretin .
Ductal cells mix their production with acinar cells to make up the pancreatic juice. [1] A diagram of the acinar cells in the pancreas, and will deliver enzymes from the acinar cells to the duodenum. [2] Ductal cells comprise about 10% of the pancreas by number and about 4% in volume.
Surface ICAM-1 in turn promotes neutrophil adhesion onto acinar cells enhancing pancreatic inflammation. [3] In addition to promoting the inflammatory cell reaction to acinar cells, ceruletide induces pancreatitis through dysregulation of digestive enzyme production and cytoplasmic vacuolization, leading to acinar cell death and pancreatic edema.