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Diphenhydramine, sold under the brand name Benadryl among others, is an antihistamine and sedative. It is a first-generation H 1-antihistamine and it works by blocking certain effects of histamine, which produces its antihistamine and sedative effects. [11] [2] Diphenhydramine is also a potent anticholinergic. [12]
The recommended dosage of Benadryl tablets for adults is 1 to 2 tablets every 4 to 6 hours, [1] and only 1 tablet every 4 to 6 hours for children under the age of 12. [2]The Benadryl challenge is an internet challenge that emerged in 2020, revolving around the deliberate consumption, excessive use and overdose of the antihistamine medicine diphenhydramine (commonly sold in the United States ...
Benadryl containing diphenhydramine can interact with alcohol as both are central nervous system (CNS) depressants. Side effects such as drowsiness and dizziness may be enhanced when taking alcohol with diphenhydramine. [16] Mixing diphenhydramine with alcohol can also increase the chances of losing consciousness due to sedation. [17]
Diphenhydramine was the prototypical agent in this group. Significant anticholinergic adverse effects, as well as sedation, are observed in this group but the incidence of gastrointestinal adverse effects is relatively low. [4] [15] Diphenhydramine; Carbinoxamine; Doxylamine; Orphenadrine; Bromazine; Clemastine; Dimenhydrinate; Alkylamines
An FAA report found that between 2012 and 2016, diphenhydramine was the most common pharmaceutical known to cause impairment detected in post-mortem toxicology tests performed on someone who may have been in charge of the aircraft at the time of a fatal plane crash, specifically naming both Benadryl and Sominex.
Mirtazapine (tetracyclic antidepressant, also has antiemetic and appetite-stimulating effects; trade name: Remeron) Olanzapine (atypical antipsychotic; trade name: Zyprexa) Olopatadine (used locally) Orphenadrine (a close relative of diphenhydramine used mainly as a skeletal muscle relaxant and anti-Parkinsons agent)
Costco tends to generate a lot of positive buzz for its grocery deals, fan-favorite baked goods, membership perks, and low-priced food court.But if there's one thing that members can't stand about ...
The first-generation sedating antihistamines diphenhydramine, doxepin, doxylamine, and pyrilamine are the most widely used medications in the world for preventing and treating insomnia. [6] As of 2004, doxylamine and diphenhydramine, which are both over-the-counter medications, were the agents most commonly used to treat short-term insomnia. [11]