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Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. [4] [8] It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon. [9]
Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
Unlike other SSRIs used to treat depression, which have been associated with high incidences of sexual dysfunction, [19] dapoxetine is associated with low rates of sexual dysfunction. Taken as needed, dapoxetine has very mild adverse effects of decreased libido (<1%) and erectile dysfunction (<4%).
The Best ED Medication for Men: Pros & Cons of Top ED Pills. Over the last 25 years, (ED) medications like Viagra and Cialis have become common fixtures in bedrooms around the world.
The most common male sexual dysfunction disorders are erectile dysfunction (ED), low libido, and ejaculatory dysfunction. Once etiology and cardiovascular risk factors for ED have been identified, lifestyle or non-pharmacological therapy can be initiated to mitigate risk factors.
Antipsychotic drugs are also responsible for several mechanisms that lead to erectile dysfunction. Mechanisms such as acetylcholine receptor antagonism and alpha-adrenergic receptor antagonism reduces periphery vasodilation, inducing erectile dysfunction. [27] Overindulgence in alcohol may also cause temporary inability to achieve an erection.