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No participants had received a COVID‑19 vaccine or been previously infected with COVID‑19. [12] The main outcome measured in the trial was the proportion of people who were hospitalized due to COVID‑19 or died due to any cause during 28 days of follow-up. [12] EPIC-HR started in July 2021, and completed in December 2021. [51]
Unless indicated otherwise, the following effectiveness ratings are indicative of clinical effectiveness two weeks after the second dose. A vaccine is generally considered effective if the estimate is ≥50% with a >30% lower limit of the 95% confidence interval. [90] Effectiveness is generally expected to slowly decrease over time. [91]
[70] [71] High efficacy is achieved with full immunization, two weeks after the second dose, and was evaluated at 94.1%: at the end of the vaccine study that led to emergency authorization in the US, there were eleven cases of COVID‑19 in the vaccine group (out of 15,181 people) versus 185 cases in the placebo group (15,170 people). [70]
Pfizer and Moderna vaccines are both safe and have similar effectiveness at preventing COVID-19 illness. Clinical trial data when they were first released in December 2020 showed 95% efficacy for ...
Companies manufacturing Covid vaccines for the US have set their price lists, and each dose will be between $120 and $130, according to reporting from Reuters. Pfizer and BioNTech set their price ...
People who are considered to have a higher risk include individuals 65 years and older, those who have cancer, HIV or are pregnant. For Paxlovid , you must be at least 12 years old and weigh 88 ...
In Com-COV2, the first dose is the Oxford–AstraZeneca vaccine or the Pfizer vaccine, and the second dose is the Moderna vaccine, the Novavax vaccine, or a homologous vaccine equal to the first dose, with an interval of 56 or 84 days between doses. [333]
Adults 65 and older, who may be at higher risk of severe COVID infection, were previously advised to get a second dose of the 2023–24 vaccine. For now, the CDC doesn’t recommend a second dose ...