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Parkinson's Disease causes constipation and gastric dysmotility that is severe enough to endanger comfort and even health. [26] A factor in this is the appearance of Lewy bodies and Lewy neurites even before these affect the functioning of the substantia nigra in the neurons in the enteric nervous system that control gut functions. [27]
Chronic secondary musculoskeletal pain due to disease of the nervous system is associated with central or peripheral nervous system conditions that are categorized elsewhere. It involves pain brought on by changes in sensory and motor function. [30] Chronic secondary musculoskeletal pain associated with Parkinson's disease
Parkinson's disease (PD), or simply Parkinson's, is a neurodegenerative disease primarily of the central nervous system, affecting both motor and non-motor systems. Symptoms typically develop gradually, with non-motor issues becoming more prevalent as the disease progresses.
Parkinsonism is a clinical syndrome characterized by the four motor symptoms found in Parkinson's disease: tremor, bradykinesia (slowed movements), rigidity, and postural instability. [ 1 ] [ 2 ] Parkinsonism gait problems can lead to falls and serious physical injuries.
Orphenadrine (sold under many brand names) [1] is an anticholinergic drug of the ethanolamine antihistamine class; it is closely related to diphenhydramine.It is a muscle relaxant that is used to treat muscle pain and to help with motor control in Parkinson's disease, but has largely been superseded by newer drugs.
In addition, patients with camptocormia often experience low back pain as a result of the condition. BSS often appears in individuals with Parkinson's disease, muscular dystrophies, endocrine disorders, inflammatory conditions , or mitochondrial myopathies. [1] As previously mentioned, the disease is more common in older individuals.