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Lithium orotate (C 5 H 3 LiN 2 O 4) is a salt of orotic acid and lithium.It is available as the monohydrate, LiC 5 H 3 N 2 O 4 ·H 2 O. [1] In this compound, lithium is non-covalently bound to an orotate ion, rather than to a carbonate or other ion, and like other salts, dissolves in solution to produce free lithium ions.
The most common side effects are lethargy and weight gain. The less common side effects of using lithium are blurred vision, a slight tremble in the hands, and a feeling of being mildly ill. In general, these side effects occur in the first few weeks after commencing lithium treatment. These symptoms can often be improved by lowering the dose. [4]
Lithium carbonate can induce a 1–2 kg of weight gain. [72] In addition to tremors, lithium treatment appears to be a risk factor for development of parkinsonism-like symptoms, although the causal mechanism remains unknown. [73] In the average bipolar patient, chronic lithium use is not associated with cognitive decline. [74]
The typical adult gains an average of 1 to 2 pounds per year, which over time, can contribute to obesity. This weight gain can be driven by physical inactivity, stress, poor sleep and poor food ...
A handful of things that can cause sudden weight gain, below. 12 Common Causes of Sudden Weight Gain You’re eating too much salt. Sodium consumption causes your body to retain water. Water has ...
In addition, the study was observational, meaning that it cannot prove cause, like that certain antidepressants cause weight gain or loss. Again, while researchers sought to focus on first-time ...
Orotic acid is a Bronsted acid and its conjugate base, the orotate anion, is able to bind to metals. Lithium orotate, for example, has been investigated for use in treating alcoholism, [4] [5] and complexes of cobalt, manganese, nickel, and zinc are known. [6]
However, many are associated with an infamous side effect: weight gain. Luckily, some antidepressants are less likely to cause weight gain than others. In fact, there are even some antidepressants ...