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A general representation of the method used to produce monoclonal antibodies [1] [2] A monoclonal antibody (mAb, more rarely called moAb) is an antibody produced from a cell lineage made by cloning a unique white blood cell. All subsequent antibodies derived this way trace back to a unique parent cell.
This technology is widely exploited in pharmaceutical industry for the discovery and development of therapeutic monoclonal antibodies to treat mainly cancer, inflammatory and infectious diseases. One of the most successful was HUMIRA ( adalimumab ), discovered by Cambridge Antibody Technology as D2E7 and developed and marketed by Abbott ...
The advent of monoclonal antibody technology has made it possible to raise antibodies against specific antigens presented on the surfaces of tumors. [3] Monoclonal antibodies can be acquired in the immune system via passive immunity or active immunity. The advantage of active monoclonal antibody therapy is the fact that the immune system will ...
In 1975, Georges Köhler, César Milstein, and Niels Kaj Jerne, succeeded in making hybridomas that made antibodies to known antigens and that were immortalized. [2] They shared the Nobel Prize in Physiology or Medicine in 1984 for the discovery. His work in laying the foundation for modern monoclonal antibody technology is recognized. [2] [3]
Niels Kaj Jerne, FRS [1] (23 December 1911 – 7 October 1994) was a Danish immunologist.He shared the Nobel Prize in Physiology or Medicine in 1984 with Georges J. F. Köhler and César Milstein "for theories concerning the specificity in development and control of the immune system and the discovery of the principle for production of monoclonal antibodies".
The principle of monoclonal antibody production, called hybridoma technology, was published in 1975 by Georges Köhler and César Milstein, [30] who were awarded the 1984 Medicine Nobel Prize for their discovery together with Niels Kaj Jerne. [31] Muromonab-CD3 was the first monoclonal antibody to be approved for clinical use in humans, in 1986 ...
In addition, Milstein foresaw the potential wealth of ligand-binding reagents that could result from applying recombinant DNA technology to monoclonal antibodies and inspired the development of the field of antibody engineering, which was to lead to safer and more powerful monoclonal antibodies for use as therapeutics.
Georges Jean Franz Köhler (German pronunciation: [ˈʒɔʁʃ ˈkøːlɐ] ⓘ; 17 April 1946 – 1 March 1995) was a German biologist.. Together with César Milstein and Niels Kaj Jerne, Köhler won the Nobel Prize in Physiology or Medicine in 1984, "for work on the immune system and the production of monoclonal antibodies".