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Gadoteric acid, sold under the brand name Dotarem among others, is a macrocycle-structured gadolinium-based MRI contrast agent (GBCA).It consists of the organic acid DOTA as a chelating agent, and gadolinium (Gd 3+), and is used in form of the meglumine salt (gadoterate meglumine).
This iron based contrast agent was never commercially launched and its development was discontinued in early 2000s due to safety concerns. [54] In 2017 GE Healthcare launched a macrocyclic extracellular gadolinium based contrast agent containing gadoteric acid as gadoterate meglumine under the trade name Clariscan. [55]
Gadoxetic acid is a gadolinium-based MRI contrast agent. [4] Its salt, gadoxetate disodium, is marketed as Primovist in Europe and Eovist in the United States by Bayer HealthCare Pharmaceuticals. [2] [5]
Gadobutrol is a medicinal product used in diagnostic magnetic resonance imaging (MRI) in adults and children. It provides contrast enhancement during cranial, spinal, breast, or other investigations. In the central nervous system, Gadobutrol works by highlighting any areas with disrupted blood brain barrier (BBB) and/or abnormal vascularity.
A contrast agent (or contrast medium) is a substance used to increase the contrast of structures or fluids within the body in medical imaging. [1] Contrast agents absorb or alter external electromagnetism or ultrasound , which is different from radiopharmaceuticals , which emit radiation themselves.
Pages in category "MRI contrast agents" The following 21 pages are in this category, out of 21 total. ... Gadoteric acid; Gadoteridol; Gadoversetamide; Gadoxetic acid ...
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The resulting aminopolycarboxylic acid, upon ionization of the carboxylic acid groups, is a high affinity chelating agent for di- and trivalent cations. The tetracarboxylic acid was first reported in 1976. [2] At the time of its discovery DOTA exhibited the largest known formation constant for the complexation of Ca 2+ and Gd 3+ ions. Modified ...