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It included 63 children who were between the ages of 3 and 17 who presented to the emergency department reporting of ear pain. Children were randomized such that 32 received placebo and 31 children received topical lignocaine prior to being offered an oral pain medication.
Acetic acid has been used medically since the time of Ancient Egypt. [8] [9] It is on the World Health Organization's List of Essential Medicines. [10] Acetic acid is more commonly used for external ear infections in the developing world than the developed. [11]
Burow's solution is an aqueous solution of aluminium triacetate.It is available in the U.S. as an over-the-counter drug for topical administration, with brand names including Domeboro (Moberg Pharma), Domeboro Otic (ear drops), Star-Otic, and Borofair. [1]
When the ear canal skin is inflamed from the acute otitis externa, the use of dilute acetic acid may be painful. Burow's solution is a very effective remedy against both bacterial and fungal external otitis. This is a buffered mixture of aluminium sulfate and acetic acid, and is available without prescription in the United States. [21]
Acetic acid/hydrocortisone is a commonly used combination drug to treat infections of the outer ear and ear canal. Branded as Vosol HC and Acetasol HC , it combines the antibacterial and antifungal action of acetic acid with the anti-inflammatory functions of hydrocortisone .
Antipyrine and benzocaine ear drops is a medication for the treatment of ear pain caused by otitis media. It combines antipyrine , an NSAID , and benzocaine , a local anaesthetic in order to treat ear pain, alongside hydroxyquinoline sulfate, an antiseptic and preservative.
Keratosis obturans is a relatively uncommon ear disease, where a dense plug of keratin, formed by abnormal accumulation of desquamated skin in sheet-like layers , forms in the bony (deeper) part of the external auditory canal. [1]
The average middle ear volume is 0.4 mL, which limits otic accumulation in overdose. [6] It is unlikely that an cerumenolytic administered into the ear would cause systemic toxicity in an overdose situation, due to the lack of systemic absorption resulting from minimal volume flow within the inner ear. [7]