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Staging breast cancer is the initial step to help physicians determine the most appropriate course of treatment. As of 2016, guidelines incorporated biologic factors, such as tumor grade, cellular proliferation rate, estrogen and progesterone receptor expression, human epidermal growth factor 2 (HER2) expression, and gene expression profiling into the staging system.
This is an accepted version of this page This is the latest accepted revision, reviewed on 14 January 2025. Cancer that originates in mammary glands Medical condition Breast cancer An illustration of breast cancer Specialty Surgical Oncology Symptoms A lump in a breast, a change in breast shape, dimpling of the skin, fluid from the nipple, a newly inverted nipple, a red scaly patch of skin on ...
Endocrine treatment may be beneficial for patients with hormone receptor positive breast tumors. [5] There are two ways for treating these kind of tumors: Lowering systemic levels of estrogen, achieved by the use of drugs from the aromatase inhibitor category. [6] [7] These drugs target one of the enzymes that takes part in the biosynthesis of ...
In the case of breast cancer, it is difficult to predict with certainty whether a tiny mass will become malignant, grow substantially, or even disappear entirely. Still, these findings prompt near ...
The central role of DNA damage and epigenetic defects in DNA repair genes in malignant neoplasms. DNA damage is considered to be the primary underlying cause of malignant neoplasms known as cancers. [18] Its central role in progression to cancer is illustrated in the figure in this section, in the box near the top.
Cancer treatments are a wide range of treatments available for the many different types of cancer, with each cancer type needing its own specific treatment. [1] Treatments can include surgery, chemotherapy, radiation therapy, hormonal therapy, targeted therapy including small-molecule drugs or monoclonal antibodies, [2] and PARP inhibitors such as olaparib. [3]
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