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The area under the effect curve (AUEC) is an integral of the effect of a drug over time, estimated as a previously-established function of concentration. It was proposed to be used instead of AUC in animal-to-human dose translation, as computer simulation shows that it could cope better with half-life and dosing schedule variations than AUC.
Approximating the area under the curve y = x 2 over [0, 2] using the right Riemann sum. Notice that because the function is monotonically increasing, the right Riemann sum will always overestimate the area contributed by each term in the sum (and do so maximally).
This method was further developed and employed by Archimedes in the 3rd century BC and used to calculate the area of a circle, the surface area and volume of a sphere, area of an ellipse, the area under a parabola, the volume of a segment of a paraboloid of revolution, the volume of a segment of a hyperboloid of revolution, and the area of a ...
A 2016 Science paper reports that the trapezoid rule was in use in Babylon before 50 BCE for integrating the velocity of Jupiter along the ecliptic. [1]In 1994, a paper titled "A Mathematical Model for the Determination of Total Area Under Glucose Tolerance and Other Metabolic Curves" was published, only to be met with widespread criticism for rediscovering the Trapezoidal Rule and coining it ...
The main criticism to the ROC curve described in these studies regards the incorporation of areas with low sensitivity and low specificity (both lower than 0.5) for the calculation of the total area under the curve (AUC)., [19] as described in the plot on the right.
The area A(x) may not be easily computable, but it is assumed to be well defined. The area under the curve between x and x + h could be computed by finding the area between 0 and x + h, then subtracting the area between 0 and x. In other words, the area of this "strip" would be A(x + h) − A(x). There is another way to estimate the
One can often quickly calculate this using the PV diagram as it is simply the area enclosed by the cycle. [citation needed] Note that in some cases specific volume will be plotted on the x-axis instead of volume, in which case the area under the curve represents work per unit mass of the working fluid (i.e. J/kg). [citation needed]
The area of a small horizontal "slab" under the graph of f, of height dy, is equal to the measure of the slab's width times dy: ({() >}). The Lebesgue integral may then be defined by adding up the areas of these horizontal slabs. From this perspective, a key difference with the Riemann integral is that the "slabs" are no longer rectangular ...