Search results
Results From The WOW.Com Content Network
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate, or uncouple, oxidative phosphorylation from ATP synthesis by dissipating the mitochondrial membrane potential as heat, also referred to as the mitochondrial proton leak.
In the damaged area of the brain after a brain injury, UP2 expression rises. In the brain, UCP2's ultimate role is in neuronal plasticity and neuronal survival. Specifically, in cerebral ischemia, studies suggest UCP2 regulates ROS production, neuroinflammation, mitochondrial potential, energy balance, neuroendocrine function, and cell death.
Mitochondrial uncoupling protein 4 is a protein that in humans is encoded by the SLC25A27 gene. [ 5 ] [ 6 ] [ 7 ] Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP).
The Houston Advanced Research Center, commonly referred to as HARC, is a 501(c)(3) not-for-profit organization based in The Woodlands, Texas with the aim of improving human and ecosystem well-being through the application of sustainability science and principles of sustainable development. HARC employs a staff of about 30 researchers and ...
Structure of the human uncoupling protein UCP1. An uncoupling protein (UCP) is a mitochondrial inner membrane protein that is a regulated proton channel or transporter.An uncoupling protein is thus capable of dissipating the proton gradient generated by NADH-powered pumping of protons from the mitochondrial matrix to the mitochondrial intermembrane space.
This will lead to protons leaking through the inner mitochondrial membrane without complexes I, III, and IV pushing protons back through to maintain the proton gradient. There is also electron leak (an event where electrons leak out of the electron transport chain), which happens because NADH dehydrogenase within Complex I becomes damaged ...
The inner mitochondrial membrane is compartmentalized into numerous folds called cristae, which expand the surface area of the inner mitochondrial membrane, enhancing its ability to produce ATP. For typical liver mitochondria, the area of the inner membrane is about five times as large as that of the outer membrane.
One is the cytoplasmic state, inhibited by carboxyatractyloside, in which the substrate binding site is accessible to the intermembrane space, which is confluent with the cytosol, i.e. the bovine mitochondrial ADP/ATP carrier 22] [23] the yeast ADP/ATP carrier Aac2p 24] the yeast ADP/ATP carrier Aac3p 24] Another is the matrix state, inhibited ...