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Cisapride is a gastroprokinetic agent, a drug that increases motility in the upper gastrointestinal tract. It acts directly as a serotonin 5-HT 4 receptor agonist and indirectly as a parasympathomimetic. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system.
Equine studies have shown that grapiprant is present in urine 96 hours after the first administration of a dose of 2 mg/kg and has a concentration >0.005 ng/ml. From the excreted dose conducted in horses, it is found that 55%, 15% and 19% of the orally-administered dose was excreted in bile, urine, and faeces respectively. [3]
Imepitoin (INN Tooltip International Nonproprietary Name), sold under the brand name Pexion, is an anticonvulsant which is used in veterinary medicine in Europe to treat epilepsy in dogs.
Mosapride is a gastroprokinetic agent that acts as a selective 5HT 4 agonist.The major active metabolite of mosapride, known as M1, additionally acts as a 5HT 3 antagonist, [1] which accelerates emptying throughout the whole of the gastrointestinal tract in humans, [2] and is used for the treatment of gastritis, gastroesophageal reflux disease, functional dyspepsia [3] and irritable bowel ...
Moreover, itopride has no affinity for the 5-HT 4 receptors, unlike other benzamides such as cisapride and mosapride, which are 5-HT 4 agonists. The affinity of cisapride for 5-HT 4 receptors in the heart has been implicated in the undesirable cardiac effects of cisapride itself. [medical citation needed]
The Merck Veterinary Manual is a reference manual of animal health care. It was first published by Merck & Co., Inc. in 1955. [1] It contains concise, thorough information on the diagnosis and treatment of disease in a wide variety of species. [2]