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  2. Sublingual administration - Wikipedia

    en.wikipedia.org/wiki/Sublingual_administration

    LSD, MDMA, morphine, alprazolam, clonazepam, diazepam, and many other substances including the psychedelic tryptamines and phenethylamines, and even recreational cannabis edibles are all viable candidates for administration via this route.

  3. Route of administration - Wikipedia

    en.wikipedia.org/wiki/Route_of_administration

    The intracerebral route can also interrupt the blood brain barrier from holding up against subsequent routes. [19] Intracerebroventricular (into the cerebral ventricles) administration into the ventricular system of the brain. One use is as a last line of opioid treatment for terminal cancer patients with intractable cancer pain. [20]

  4. Diazepam - Wikipedia

    en.wikipedia.org/wiki/Diazepam

    The distribution half-life of diazepam is two to 13 minutes. [20] Diazepam is highly lipid-soluble and is widely distributed throughout the body after administration. It easily crosses both the blood–brain barrier and the placenta, and is excreted into breast milk. After absorption, diazepam is redistributed into muscle and adipose tissue.

  5. Palliative sedation - Wikipedia

    en.wikipedia.org/wiki/Palliative_sedation

    In medicine, specifically in end-of-life care, palliative sedation (also known as terminal sedation, continuous deep sedation, or sedation for intractable distress of a dying patient) is the palliative practice of relieving distress in a terminally ill person in the last hours or days of a dying person's life, usually by means of a continuous intravenous or subcutaneous infusion of a sedative ...

  6. Subcutaneous administration - Wikipedia

    en.wikipedia.org/wiki/Subcutaneous_administration

    Subcutaneous administration is the insertion of medications beneath the skin either by injection or infusion. A subcutaneous injection is administered as a bolus into the subcutis, the layer of skin directly below the dermis and epidermis, collectively referred to as the cutis. The instruments are usually a hypodermic needle and a syringe.

  7. Effects of long-term benzodiazepine use - Wikipedia

    en.wikipedia.org/wiki/Effects_of_long-term...

    Three of the 50 patients had wrongly been given a preliminary diagnosis of multiple sclerosis when the symptoms were actually due to chronic benzodiazepine use. Ten of the patients had taken drug overdoses whilst on benzodiazepines, despite the fact that only two of the patients had any prior history of depressive symptomatology. After ...

  8. Benzodiazepine - Wikipedia

    en.wikipedia.org/wiki/Benzodiazepine

    [206] [207] Following chlordiazepoxide, diazepam marketed by Hoffmann–La Roche under the brand name Valium in 1963, and for a while the two were the most commercially successful drugs. The introduction of benzodiazepines led to a decrease in the prescription of barbiturates , and by the 1970s they had largely replaced the older drugs for ...

  9. List of benzodiazepines - Wikipedia

    en.wikipedia.org/wiki/List_of_benzodiazepines

    The changes are most notable with long acting benzodiazepines as these are prone to significant accumulation in such individuals and can lead to withdrawal symptoms. [citation needed] For example, the equivalent dose of diazepam in an elderly individual on lorazepam may be half of what would be expected in a younger individual.