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Necrotizing fasciitis (NF), also known as flesh-eating disease, is an infection that kills the body's soft tissue. [3] It is a serious disease that begins and spreads quickly. [ 3 ] Symptoms include red or purple or black skin, swelling, severe pain, fever , and vomiting. [ 3 ]
The treatment of choice is penicillin, and the duration of treatment is around 10 days. [23] Antibiotic therapy (using injected penicillin) has been shown to reduce the risk of acute rheumatic fever. [24] In individuals with a penicillin allergy, erythromycin, other macrolides, and cephalosporins have been shown to be effective treatments. [25]
The clinical presentation among invasive disease is also dominated by skin and soft tissue infections, including a small subset of patients presenting with severe necrotizing fasciitis. [1] [2] Moreover, it is an important cause of bone and joint infections, and this disease manifestation is reported to be increasing. [12]
Fasciitis is an inflammation of the fascia, [1] which is the connective tissue surrounding muscles, blood vessels and nerves. In particular, it often involves one of the following diseases: Necrotizing fasciitis
Toxic shock syndrome (TSS) is a condition caused by bacterial toxins. [1] Symptoms may include fever, rash, skin peeling, and low blood pressure. [1] There may also be symptoms related to the specific underlying infection such as mastitis, osteomyelitis, necrotising fasciitis, or pneumonia.
The route of administration of an antibiotic varies. Antibiotics effective against MRSA can be given by IV, oral, or a combination of both, and depend on the specific circumstances and patient characteristics. [4] The use of concurrent treatment with vancomycin or other beta-lactam agents may have a synergistic effect. [21]: 637
Peptostreptococcus can cause brain, liver, breast, and lung abscesses, as well as generalized necrotizing soft tissue infections. They participate in mixed anaerobic infections , a term which is used to describe infections that are caused by multiple bacteria that do not require or may even be harmed by oxygen.
Infectious lymphangitis should be differentiated from other conditions such as superficial thrombophlebitis (swelling is local to the affected vein), cat scratch (swellings feels hard to the touch), acute streptococcal hemolytic gangrene and necrotizing fasciitis (infected area crackles to the touch and the patient looks very ill). [citation ...