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Maropitant (INN; [3] brand name: Cerenia, used as maropitant citrate , is a neurokinin-1 (NK 1) receptor antagonist developed by Zoetis specifically for the treatment of motion sickness and vomiting in dogs. It was approved by the FDA in 2007, for use in dogs [4] [5] and in 2012, for cats. [6]
Ezetimibe, sold under the brand name Zetia among others, is a medication used to treat high blood cholesterol and certain other lipid abnormalities. [ 3 ] [ 4 ] Generally it is used together with dietary changes and a statin . [ 5 ]
It is a combination of ezetimibe (known as Zetia in the United States) and the statin drug simvastatin (known as Zocor in the US). Ezetimibe reduces blood cholesterol by acting at the brush border of the small intestine and inhibiting the absorption of cholesterol, leading to a decrease in the delivery of intestinal cholesterol to the liver.
There are a limited number of non-surgical fertility control options available for cats and dogs, which vary in effectiveness, duration of action and safety. Progestin contraceptives are approved for contraception in male and female dogs and cats in multiple countries. Typically approval is for a few months of use.
Studies in animals such as horses have shown the presence of grapiprant in serum 72 hours with a concentration >0.005 ng/mL after the initial administration of a dose of 2 mg/kg. Grapiprant is expeditiously absorbed and the reported serum concentration was reported to be 31.9 ng/ml in an amount of time of 1.5 hours.
Individual dogs of any breed can have a profound reaction characterized by hypotension, especially if there is an underlying heart problem. In giant-breed dogs and sighthounds , the sedative effects of acepromazine may last for 12–24 hours, which is much longer than the usual 3–4 hours.
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It is particularly used for infections of the skin, respiratory system and mammary glands in dogs and cats, as well as with urinary tract infections. For dogs, a dose ranges from 2.75 - 5.5 mg/kg once a day. The duration of treatment is usually at least five days, longer if there is a concurrent fungal or yeast infection. [4]