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Photodynamic therapy (PDT) is a form of phototherapy involving light and a photosensitizing chemical substance used in conjunction with molecular oxygen to elicit cell death (phototoxicity). [ 1 ] PDT is used in treating acne , wet age-related macular degeneration , psoriasis , and herpes .
Joan Miller (née Whitten) was born in Toronto, Canada, and attended Bishop Strachan School. [1] She received her SB in biology from Massachusetts Institute of Technology, where she also rowed crew for four years, taking 2nd place in the Head of the Charles Regatta in 1978 and 3rd nationally in 1980. [2]
Though photopharmacology is a relatively new field, the concept of using light in therapeutic applications came into practice a few decades ago. Photodynamic therapy (PDT) is a well-established clinically practiced protocol in which photosensitizers are used to produce singlet oxygen for destroying diseased or damaged cells or tissues. [2]
Dental infections tend to also respond better to photothermal therapy than photodynamic therapy, though both have a strong effect. [10] [11] [12] The efficacy of PDT for antimicrobial usage is limited by the properties of the membrane of the target cell such as the electrical gradient (membrane potential) and lipid composition.
The efficacy of antimicrobial photodynamic therapy, using various distinct photosensitizers, has been studied since the 1990s. [ 9 ] [ 7 ] Most studies have yielded positive outcomes, often achieving disinfection levels, as defined by infection control guidelines, exceeding 5 log 10 (99.999%) of microbial inactivation. [ 14 ]
Recently, central serous chorioretinopathy has been understood to be part of the pachychoroid spectrum. [5] [6] In pachychoroid spectrum disorders, of which CSR represents stage II, the choroid, the highly vascularized layer below the retina, is thickened and congested with increased blood vessel diameter, especially in the deep choroid (the so-called Haller's layer).
(96567–96571) photodynamic therapy (96900–96999) special dermatological procedures (97001–97799) physical medicine and rehabilitation (97802–97804) medical nutrition therapy (97810–97814) acupuncture (98925–98929) osteopathic manipulative treatment (98940–98943) chiropractic manipulative treatment
Photodynamic therapy (PDT) is a form of phototherapy using nontoxic light-sensitive compounds (photosensitizers) that are exposed selectively to light at a controlled wavelength, laser intensity, and irradiation time, whereupon they generate toxic reactive oxygen species (ROS) that target malignant and other diseased cells.