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In humans, the SRY gene is located on short (p) arm of the Y chromosome at position 11.2. Sex-determining region Y protein (SRY), or testis-determining factor (TDF), is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRY gene that is responsible for the initiation of male sex determination in therian mammals (placentals and marsupials). [5]
The SRY gene, normally found on the Y chromosome, plays an important role in sex determination by initiating testicular development. In about 80 percent of XX males, the SRY gene is present on one of the X chromosomes. [16] [25] The condition results from an abnormal exchange of genetic material between chromosomes (translocation).
The Y chromosome is one of two sex chromosomes in therian mammals and other organisms.Along with the X chromosome, it is part of the XY sex-determination system, in which the Y is the sex-determining chromosome because the presence of the Y chromosome causes offspring produced in sexual reproduction to be of male sex.
6657 20674 Ensembl ENSG00000181449 ENSMUSG00000074637 UniProt P48431 P48432 RefSeq (mRNA) NM_003106 NM_011443 RefSeq (protein) NP_003097 NP_035573 Location (UCSC) Chr 3: 181.71 – 181.71 Mb Chr 3: 34.7 – 34.71 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self ...
The human Y chromosome showing the SRY gene which codes for a protein regulating sexual differentiation. Sexual differentiation in humans is the process of development of sex differences in humans. It is defined as the development of phenotypic structures consequent to the action of hormones produced following gonadal determination. [1]
SOX genes (SRY-related HMG-box genes) encode a family of transcription factors that bind to the minor groove in DNA, and belong to a super-family of genes characterized by a homologous sequence called the HMG-box (for high mobility group). This HMG box is a DNA binding domain that is highly conserved throughout eukaryotic species.
6662 20682 Ensembl ENSG00000125398 ENSMUSG00000000567 UniProt P48436 Q04887 RefSeq (mRNA) NM_000346 NM_011448 RefSeq (protein) NP_000337 NP_035578 Location (UCSC) Chr 17: 72.12 – 72.13 Mb Chr 11: 112.67 – 112.68 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transcription factor SOX-9 is a protein that in humans is encoded by the SOX9 gene. Function SOX-9 recognizes the sequence ...
The gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, located on Chromosome 8 q11.23. Its gene body is isolated within a CTCF loop domain. [ 6 ] [ 7 ] [ 8 ] Approximately 230 kb upstream of SOX17 it has been identified a tissue specific differentially (hypo-)methylated region (DMR), which consists of SOX17 ...