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This was from the notion that depression was primarily due to norepinephrine deficits, partly based on the fact that drugs that relieve depression increase brain norepinephrine levels. [28] To date, a great number of potent and selective and mixed norepinephrine reuptake inhibitors (NRIs) have been marketed as antidepressants. [11]
About one in 10 people have restless leg syndrome, but the cause is a mystery. ... (Mirapex) are approved by the FDA for the treatment of moderate to severe RLS. Drugs affecting calcium channels. ...
Restless legs syndrome (RLS), (also known as Willis–Ekbom disease (WED), is a neurological disorder, usually chronic, that causes an overwhelming urge to move one's legs. [ 2 ] [ 10 ] There is often an unpleasant feeling in the legs that improves temporarily by moving them. [ 2 ]
Pramipexole is used in the treatment of Parkinson's disease and restless legs syndrome. [8] Safety in pregnancy and breastfeeding is unknown. [1] A 2008 meta-analysis found that pramipexole was more effective than ropinirole in the treatment of restless legs syndrome. [12] It is occasionally prescribed off-label for depression.
Since the release of nonbenzodiazepines, also known as z-drugs, in 1992 in response to safety concerns, individuals with insomnia and other sleep disorders have increasingly been prescribed nonbenzodiazepines (2.3% in 1993 to 13.7% of Americans in 2010), less often prescribed benzodiazepines (23.5% in 1993 to 10.8% in 2010).
However, despite a lack of historical association between restless leg syndrome and akathisia, this does not guarantee that the two conditions do not share symptoms in individual cases. [2] If akathisia is caused by an antipsychotic, treatment may include switching to an antipsychotic with a lower risk of the condition. [2]
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