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Giant cell arteritis may present with atypical or overlapping features. [15] Early and accurate diagnosis is important to prevent ischemic vision loss. Therefore, this condition is considered a medical emergency. [15] While studies vary as to the exact relapse rate of giant cell arteritis, relapse of this condition can occur. [16]
AAION is due to temporal arteritis (also called giant-cell arteritis), an inflammatory disease of medium-sized blood vessels (Chapel-Hill-Conference) that occurs especially with advancing age. In contrast, NAION results from the coincidence of cardiovascular risk factors in a patient with "crowded" optic discs.
Sudden visual loss is the most common symptom in AAION, [1] and is most often accompanied by other symptoms of temporal arteritis: such as jaw claudication, scalp tenderness, unintentional weight loss, fatigue, myalgias and loss of appetite. [1] A related disease called polymyalgia rheumatica has a 15 percent incidence of giant cell arteritis.
Arteritis is a vascular disorder characterized by inflammation of the walls of arteries, [1] usually as a result of infection or autoimmune responses. Arteritis, a complex disorder, is still not entirely understood. [2] Arteritis may be distinguished by its different types, based on the organ systems affected by the disease. [2]
Scottish otolaryngologist Peter McBride (1854–1946) first described the condition in 1897 in a British Medical Journal article entitled "Photographs of a case of rapid destruction of the nose and face". [32] Heinz Karl Ernst Klinger (born 1907) added information on the anatomical pathology.
Giant cell arteritis (GCA) is the most common type of systemic vasculitis in adults. Polymyalgia rheumatica (PMR), headache, jaw claudication , and visual symptoms are the classic manifestations; however, 40% of patients present with a variety of occult manifestations.
A giant cell (also known as a multinucleated giant cell, or multinucleate giant cell) is a mass formed by the union of several distinct cells (usually histiocytes), often forming a granuloma. [ 1 ] Although there is typically a focus on the pathological aspects of multinucleate giant cells (MGCs), they also play many important physiological roles.
Magnetic resonance angiography (MRA) is a group of techniques based on magnetic resonance imaging (MRI) to image blood vessels. Magnetic resonance angiography is used to generate images of arteries (and less commonly veins) in order to evaluate them for stenosis (abnormal narrowing), occlusions, aneurysms (vessel wall dilatations, at risk of rupture) or other abnormalities.