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Benzyl chloroformate is commonly used in organic synthesis for the introduction of the benzyloxycarbonyl (formerly called carboxybenzyl) protecting group for amines.The protecting group is abbreviated Cbz or Z (in honor of discoverer Zervas), hence the alternative shorthand designation for benzyl chloroformate as Cbz-Cl or Z-Cl.
Orthogonal protection is a strategy allowing the specific deprotection of one protective group in a multiply-protected structure. For example, the amino acid tyrosine could be protected as a benzyl ester on the carboxyl group, a fluorenylmethylenoxy carbamate on the amine group, and a tert -butyl ether on the phenol group.
Benzyl carbamate is the organic compound with the formula C 6 H 5 CH 2 OC(O)NH 2. The compound can be viewed as the ester of carbamic acid (O=C(OH)(NH 2)) and benzyl alcohol, although it is produced from benzyl chloroformate with ammonia. [1] It is a white solid that is soluble in organic solvents and moderately soluble in water.
Benzyl group and derivatives: Benzyl group, benzyl radical, benzyl amine, benzyl bromide, benzyl chloroformate, and benzyl methyl ether. R = heteroatom, alkyl, aryl, allyl etc. or other substituents. In organic chemistry, benzyl is the substituent or molecular fragment possessing the structure R−CH 2 −C 6 H 5.
For example, benzyl chloroformate is used to introduce the Cbz (carboxybenzyl) protecting group and fluorenylmethyloxycarbonyl chloride is used to introduce the FMOC protecting group. Chloroformates are popular in the field of chromatography as derivatization agents.
When it comes to who these companies are protecting, a surprising number think about more than just the chief operating officer. Around 37% reported having security measures solely for their CEO ...
The (Z) group is another carbamate-type amine protecting group, discovered by Leonidas Zervas in the early 1930s and usually added via reaction with benzyl chloroformate. [34] Introduction of the Z protecting group from reaction with benzyl chloroformate (Z-chloride)
The biggest tech companies in the world are shelling out millions of dollars every year to protect their CEOs—but some pay more than others, and for good reason.