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Irwin Fridovich and Joe McCord at Duke University discovered the enzymatic activity of superoxide dismutase in 1968. [5] SODs were previously known as a group of metalloproteins with unknown function; for example, CuZnSOD was known as erythrocuprein (or hemocuprein, or cytocuprein) or as the veterinary anti-inflammatory drug "Orgotein". [6]
Superoxide dismutase 2, mitochondrial (SOD2), also known as manganese-dependent superoxide dismutase (MnSOD), is an enzyme which in humans is encoded by the SOD2 gene on chromosome 6. [ 5 ] [ 6 ] A related pseudogene has been identified on chromosome 1.
20657 Ensembl ENSG00000109610 ENSMUSG00000072941 UniProt P08294 O09164 RefSeq (mRNA) NM_003102 NM_011435 RefSeq (protein) NP_003093 NP_035565 Location (UCSC) Chr 4: 24.79 – 24.8 Mb Chr 5: 52.52 – 52.53 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Extracellular superoxide dismutase [Cu-Zn] is an enzyme that in humans is encoded by the SOD3 gene. This gene encodes a member of ...
A Madagascar hissing cockroach crawls on a stick at Idlewild Butterfly Farm in Louisville, Kentucky on July 21, 2023. My Bloody Valentine at WildCat Ridge Sanctuary.
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The Lunar greenhouse is an underground farm made by Phil Sadles and Gene Giacomelli of the University of Arizona's Controlled Environment Agriculture Center (CEAC) [4] [5] The urine and exhaled air of the astronauts is reused in the system by the plants. [6] GreenForges is a Canadian startup developing underground farming systems. [7] [8] [9]
SOD1 binds copper and zinc ions and is one of three superoxide dismutases responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic and mitochondrial intermembrane space protein, acting as a homodimer to convert naturally occurring, but harmful, superoxide radicals to molecular oxygen and hydrogen peroxide.