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The myosin-binding protein C, cardiac-type is a protein that in humans is encoded by the MYBPC3 gene. [5] This isoform is expressed exclusively in heart muscle during human and mouse development, [ 6 ] and is distinct from those expressed in slow skeletal muscle ( MYBPC1 ) and fast skeletal muscle ( MYBPC2 ).
In the thick myofilaments of the heart tissue, the predominant gene mutations occur in “myosin-binding protein C (MYBPC3)” and “myosin heavy chain (MYH7).” Myocardial infarction, atrial fibrillation, ventricular fibrillation, embolic events, and/or congestive heart failure are all possible outcomes of this condition.
Illustration of a Normal Heart vs. Heart with Dilated Cardiomyopathy. The progression of heart failure is associated with left ventricular remodeling, which manifests as gradual increases in left ventricular end-diastolic and end-systolic volumes, wall thinning, and a change in chamber geometry to a more spherical, less elongated shape.
4606 233199 Ensembl ENSG00000086967 ENSMUSG00000038670 UniProt Q14324 Q5XKE0 RefSeq (mRNA) NM_004533 NM_146189 RefSeq (protein) NP_004524 NP_666301 Location (UCSC) Chr 19: 50.43 – 50.47 Mb Chr 7: 44.15 – 44.17 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Myosin binding protein C, fast type is a protein that in humans is encoded by the MYBPC2 gene. Function This gene encodes a ...
MHC-β is a 223 kDa protein composed of 1935 amino acids. [7] [8] MHC-β is a hexameric, asymmetric motor forming the bulk of the thick filament in cardiac muscle.MHC-β is composed of N-terminal globular heads (20 nm) that project laterally, and alpha helical tails (130 nm) that dimerize and multimerize into a coiled-coil motif to form the light meromyosin (LMM), thick filament rod. [9]
Heart failure with recovered ejection fraction (HFrecovEF or HFrecEF): patients previously with HFrEF with complete normalization of left ventricular ejection (≥50%). [64] [65] Heart failure may also be classified as acute or chronic. Chronic heart failure is a long-term condition, usually kept stable by the treatment of symptoms.