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Toxicodynamics, termed pharmacodynamics in pharmacology, describes the dynamic interactions of a toxicant with a biological target and its biological effects. [1] A biological target , also known as the site of action, can be binding proteins, ion channels , DNA , or a variety of other receptors.
Toxicodynamics (TD) and pharmacodynamics (PD) link a therapeutic agent or toxicant, or toxin (xenobiotic)'s dosage to the features, amount, and time course of its biological action. [11] The mechanism of action is a crucial factor in determining effect and toxicity of the drug, taking in consideration the pharmacokinetic (PK) factors. [12]
It is an application of pharmacokinetics to determine the relationship between the systemic exposure of a compound and its toxicity.It is used primarily for establishing relationships between exposures in toxicology experiments in animals and the corresponding exposures in humans.
Protoxin-I, also known as ProTx-I, or Beta/omega-theraphotoxin-Tp1a, is a 35-amino-acid peptide neurotoxin extracted from the venom of the tarantula Thrixopelma pruriens. ...
In toxicodynamics and pharmacodynamics, Loewe additivity (or dose additivity) is one of several common reference models used for measuring the effects of drug combinations. [ 1 ] [ 2 ] [ 3 ] Definition
Toxicodynamics This page was last edited on 29 August 2020, at 17:48 (UTC). Text is available under the Creative ... Contact Wikipedia; Code of Conduct; Developers;
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Abrin is an extremely toxic toxalbumin found in the seeds of the rosary pea (or jequirity pea), Abrus precatorius.It has a median lethal dose of 0.7 micrograms per kilogram of body mass when given to mice intravenously (approximately 3.86 times more toxic than ricin, being 2.7 micrograms per kilogram). [1]