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Toxicodynamics, termed pharmacodynamics in pharmacology, describes the dynamic interactions of a toxicant with a biological target and its biological effects. [1] A biological target , also known as the site of action, can be binding proteins, ion channels , DNA , or a variety of other receptors.
Toxicodynamics (TD) and pharmacodynamics (PD) link a therapeutic agent or toxicant, or toxin (xenobiotic)'s dosage to the features, amount, and time course of its biological action. [11] The mechanism of action is a crucial factor in determining effect and toxicity of the drug, taking in consideration the pharmacokinetic (PK) factors. [12]
Four potential processes exist for a chemical interacting with an animal: absorption, distribution, metabolism and excretion (ADME).Absorption describes the entrance of the chemical into the body, and can occur through the air, water, food, or soil.
In toxicodynamics and pharmacodynamics, Loewe additivity (or dose additivity) is one of several common reference models used for measuring the effects of drug combinations. [ 1 ] [ 2 ] [ 3 ] Definition
Toxicodynamics This page was last edited on 29 August 2020, at 17:48 (UTC). Text is available under the Creative ... Contact Wikipedia; Code of Conduct; Developers;
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A toxicologist working in a lab (United States, 2008)Toxicology is a scientific discipline, overlapping with biology, chemistry, pharmacology, and medicine, that involves the study of the adverse effects of chemical substances on living organisms [1] and the practice of diagnosing and treating exposures to toxins and toxicants.
Copper toxicity (or Copperiedus) is a type of metal poisoning caused by an excess of copper in the body. Copperiedus could occur from consuming excess copper salts, but most commonly it is the result of the genetic condition Wilson's disease and Menke's disease, which are associated with mismanaged transport and storage of copper ions.