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It was discovered in 2000 as one of two improved mutants by H. Bujard and his colleagues after random mutagenesis of the Tet repressor part of the transactivator gene. [6] Tet-On 3G (also known as rtTA-V10 [7]) is similar to Tet-On Advanced but was derived from rtTA2 S-S2 rather than rtTA2 S-M2. It is also human codon optimized and composed of ...
The transactivator gene expresses a transcription factor that binds to specific promoter region of DNA. By binding to the promoter region of a gene, the transcription factor causes that gene to be expressed. The expression of one transactivator gene can activate multiple genes, as long as they have the same, specific promoter region attached.
21752 Ensembl ENSG00000164362 ENSMUSG00000021611 UniProt O14746 O70372 RefSeq (mRNA) NM_001193376 NM_198253 NM_198254 NM_198255 NM_009354 NM_001362387 NM_001362388 RefSeq (protein) NP_001180305 NP_937983 NP_033380 NP_001349316 NP_001349317 Location (UCSC) Chr 5: 1.25 – 1.3 Mb Chr 13: 73.78 – 73.8 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Telomerase reverse transcriptase ...
At the time of launch, Microsoft deemed Windows 7 (with Service Pack 1) and Windows 8.1 users eligible to upgrade to Windows 10 free of charge, so long as the upgrade took place within one year of Windows 10's initial release date. Windows RT and the respective Enterprise editions of Windows 7, 8, and 8.1 were excluded from this offer.
Tet Repressor proteins (otherwise known as TetR) are proteins playing an important role in conferring antibiotic resistance to large categories of bacterial species. Tetracycline (Tc) is a broad family of antibiotics to which bacteria have evolved resistance. Tc normally kills bacteria by binding to the bacterial ribosome and halting protein ...
Thus TET enzymes largely initiate demethylation at 5mCpG sites. Oxoguanine glycosylase (OGG1) is one example of a protein that recruits a TET enzyme. TET1 is able to act on 5mCpG if an ROS has first acted on the guanine to form 8-hydroxy-2'-deoxyguanosine (8-OHdG or its tautomer 8-oxo-dG), resulting in a 5mCp-8-OHdG dinucleotide (see Figure). [10]
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Firstly, it binds with high affinity to Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), found on the inner surface of the cell membrane, to facilitate Tat recruitment. Tat then crosses the plasma membrane to reach the extracellular space. Tat secretion by infected cells is highly active, and export is the major destination for HIV-1 Tat. [2]