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Nasal polyps resulting from chronic rhinosinusitis affect approximately 4.3% of the population. [6] Nasal polyps occur more frequently in men than women and are more common as people get older, increasing drastically after the age of 40. [6] Of people with chronic rhinosinusitis, 10% to 54% also have allergies.
Aspirin-exacerbated respiratory disease (AERD), also called NSAID-exacerbated respiratory disease (N-ERD) or historically aspirin-induced asthma and Samter's Triad, is a long-term disease defined by three simultaneous symptoms: asthma, chronic rhinosinusitis with nasal polyps, and intolerance of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs).
Some polyps are tumors and others are non-neoplastic, for example hyperplastic or dysplastic, which are benign. The neoplastic ones are usually benign, although some can be pre-malignant, or concurrent with a malignancy. The name is of ancient origin, in use in English from about 1400 for a nasal polyp, from Latin polypus through Greek. [1]
It is divided into two phenotypes that depend on the presence or absence of nasal polyps. [61] Chronic rhinosinusitis with nasal polyps and chronic rhinosinusitis without nasal polyps are thought to have two different inflammatory pathways, with the latter form driven by a Th1 response and the former driven by a Th2 response. [62]
It can be caused by anatomical factors such as a deviated septum or nasal polyps (growths), as well as infection. Symptoms include difficulty breathing through the nose, swelling and pain around the nose and eyes, postnasal drainage down the throat, and difficulty sleeping. [10] CRS is a common condition in children and young adults. [11]
Polyps with asthma; Angioedema; Rhinitis, sinusitis, nasal polyps; Asthma and nasal polyps are also symptoms of aspirin-exacerbated respiratory disease (AERD, Samter's Triad), which is not believed to be caused by dietary salicylates.
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