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Spindle-cell hemangioendothelioma [3]) is a vascular tumor that was first described in 1986 by Sharon Weiss, M.D., [4] and commonly presents in a child or young adult who develops blue nodules of firm consistency on a distal extremity.
A vascular tumor is a vascular anomaly where a tumor forms from cells that make blood or lymph vessels; a soft tissue growth that can be either benign or malignant. [1] Examples of vascular tumors include hemangiomas, hemangioendotheliomas, Kaposi's sarcomas, angiosarcomas, and hemangioblastomas. An angioma refers to any type of benign vascular ...
Hemangiopericytomas are tumors that are derived from specialized spindle shaped cells called pericytes, which line capillaries. [4] Hemangiopericytoma is an aggressive mesenchymally derived tumor with oval nuclei with scant cytoplasm. There is dense intercellular reticulin staining. Tumor cells can be fibroblastic, myxoid, or pericytic. These ...
A hemangioma or haemangioma is a usually benign vascular tumor derived from blood vessel cell types. The most common form, seen in infants, is an infantile hemangioma, known colloquially as a "strawberry mark", most commonly presenting on the skin at birth or in the first weeks of life. A hemangioma can occur anywhere on the body, but most ...
Epithelioid hemangioendothelioma, a vascular tumour occurring in the lining of blood vessels; Epithelioid blue nevus, a melanocytic nevus; Epithelioid sarcoma-like hemangioendothelioma, a group of vascular neoplasms; Epithelioid and spindle-cell nevus, a benign melanocytic lesion affecting the epidermis and dermis; Epithelioid hemangioma
[8] [14] There are fibrin thrombi, inflammatory lymphocytic aggregates, and extensive red blood cell extravasation. [ 5 ] [ 8 ] [ 14 ] Later stages show significant hemosiderin deposition in the stroma, fibrosis , and a collapsed appearance of the arterial lumen.
Spindle cell sarcoma is a type of connective tissue cancer. The tumors generally begin in layers of connective tissue , as found under the skin, between muscles, and surrounding organs, and will generally start as a small, inflamed lump, which grows in size.
Pericytes envelop the endothelial cells, [9] which can exhibit a combination of plump and flat cells without pleomorphism or mitotic patterns. [10] Immunohistochemically, an microvenular hemangioma's endothelial cells show positive staining for CD31, CD34, and factor VIII, while its pericytes show positive staining for SMA.