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Melanonychia is a black or brown pigmentation of a nail, and may be present as a normal finding on many digits in Afro-Caribbeans, as a result of trauma, systemic disease, or medications, or as a postinflammatory event from such localized events as lichen planus or fixed drug eruption.
Hyperpigmentation can be diffuse or focal, affecting such areas as the face and the back of the hands. Melanin is produced by melanocytes at the lower layer of the epidermis. Melanin is a class of pigment responsible for producing color in the body in places such as the eyes, skin, and hair.
Alopecia, dental anomalies, and dystrophic nails are observed. Some patients have retinal vascular abnormalities predisposing to retinal detachment in early childhood. Cognitive delays or intellectual disability are occasionally seen. [citation needed] The discolored skin is caused by excessive deposits of melanin (normal skin pigment). Most ...
The actual skin colour of different humans is affected by many substances, although the single most important substance determining human skin colour is the pigment melanin. Melanin is produced within the skin in cells called melanocytes and it is the main determinant of the skin colour of darker-skinned humans.
Half and half nails (also known as "Lindsay's nails") show the proximal portion of the nail white and the distal half red, pink, or brown, with a sharp line of demarcation between the two halves. [ 1 ] : 785 The darker distal discoloration does not fade on pressure, [ 2 ] which differentiates Lindsay's nails from Terry's nails .
Melanosomes, which are organelles containing melanin, must be transported and increased during hyperpigmentation and tanning, while they shrink during hypopigmentation. [4] Skin pigmentation is frequently caused by sun exposure. To protect itself against UV radiation from the sun, the body makes more melanin. As a result, the skin may become ...
This is an accepted version of this page This is the latest accepted revision, reviewed on 28 December 2024. "Skin pigmentation" redirects here. For animal skin pigmentation, see Biological pigment. Extended Coloured family from South Africa showing some spectrum of human skin coloration Human skin color ranges from the darkest brown to the lightest hues. Differences in skin color among ...
Drug/Drug Group Clinical Features [1]; NSAIDs: Purple, red, yellow, slate, or blue-grey pigmented macules on the extremities and trunk – drug eruption: Antimalarials: Blue-ish pigmentation of lower extremities, but can also involve the entire nail bed, nose, cheeks, forehead, ears, and oral mucosa