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The semisynthetic pneumocandin analogs of echinocandins were later found to have the same kind of antifungal activity, but low toxicity. The first of these newer echinocandins to be approved by the U.S. Food and Drug Administration was caspofungin, and later micafungin and anidulafungin were also approved.
Caspofungin (INN; [1] [4] brand name Cancidas) is a lipopeptide antifungal drug from Merck & Co., Inc.. [5] It is a member of a class of antifungals termed the echinocandins. [medical citation needed] It works by inhibiting the enzyme (1→3)-β-D-glucan synthase and thereby disturbing the integrity of the fungal cell wall.
Rezafungin, sold under the brand name Rezzayo (by Melinta Therapeutics), is a medication used for the treatment of invasive candidiasis. [2] It is an echinocandin antifungal [1] [4] that acts as a fungal β-glucan synthase inhibitor.
It is a member of the class of antifungal drugs known as the echinocandins; its mechanism of action is by inhibition of (1→3)-β-D-glucan synthase, an enzyme important to the synthesis of the fungal cell wall. [7] It is on the World Health Organization's List of Essential Medicines. [8]
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Pneumocandin B 0 is the starting molecule for the first semisynthetic echinocandin antifungal drug, caspofungin acetate. [citation needed]In the wild-type strain, pneumocandin B 0 is a minor fermentation product, and its industrial production was achieved by a combination of extensive mutation and medium optimization.
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