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Tetralin (1,2,3,4-tetrahydronaphthalene) is a hydrocarbon having the chemical formula C 10 H 12. It is a partially hydrogenated derivative of naphthalene . It is a colorless liquid that is used as a hydrogen-donor solvent .
6-(2-Aminopropyl)tetralin (6-APT), also sometimes called tetralinylaminopropane (TAP), is a drug of the amphetamine class which acts as a selective serotonin releasing agent (SSRA). [1] It has IC 50 values of 121 nM, 6,436 nM, and 3,371 nM for inhibiting the reuptake of serotonin , dopamine , and norepinephrine , respectively. [ 1 ]
Tetralin is used as a hydrogen-donor solvent. [25] Alkylation of naphthalene with propylene gives a mixture of diisopropylnaphthalenes, which are useful as nonvolatile liquids for inks. [25] Substituted naphthalenes serve as pharmaceuticals such as propranolol (a beta blocker) and nabumetone (a nonsteroidal anti-inflammatory drug).
8-OH-DPAT is a research chemical of the aminotetralin chemical class which was developed in the 1980s and has been widely used to study the function of the 5-HT 1A receptor.It was one of the first major 5-HT 1A receptor full agonists to have been discovered.
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It is a ketone derivative of tetralin, a hydrogenated derivative of naphthalene. History and synthesis
2-Aminotetralin (2-AT), also known as 1,2,3,4-tetrahydronaphthalen-2-amine (THN), is a stimulant drug with a chemical structure consisting of a tetralin group combined with an amine. [1] [2] 2-AT is a rigid analogue of phenylisobutylamine and fully substitutes for d-amphetamine in rat drug discrimination tests, although at one-half to one ...
As already described in 1933 by Heinrich Hock, 1,2,3,4-tetrahydronaphthalene tends to autoxidize and gradually forms the 1-hydroperoxide with atmospheric oxygen. [7] The heavy metal ion catalyzed air oxidation of 1,2,3,4-tetrahydronaphthalene with Cr 3+ [8] or Cu 2+ in the liquid phase leads via the hydroperoxide to a mixture of the intermediate 1-tetralol and the final product 1-tetralone.