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Five years after receiving a life-changing stem cell transplant, a 68-year-old man says he’s “extremely grateful” to be essentially cured of acute myelogenous leukemia and in HIV remission.
Treated with a stem cell transplant for AML in 2013, Franke, 55, went off antiretrovirals in November 2018 and is considered cured. Marc Franke, the Paul Edmonds , aka the “ City of Hope patient
Brown stopped taking his antiretroviral medication on the day of his first transplant. Three months after the first stem cell transplant, levels of HIV rapidly plummeted to undetectable levels while his CD4 T cell count increased. In addition, blood and tissue samples from areas of the body where HIV is known to hide were tested.
His journey to recovery, culminating in a stem cell transplant in 2019, at age 63, involved a donor with a rare genetic mutation (homozygous CCR5 Delta 32) resistant to most HIV strains. Edmonds ceased his HIV treatment in March 2021, with subsequent tests revealing no evidence of HIV in his body.
The patient has been off HIV medication for four years without relapse.
Donor lymphocyte infusion is the infusion in which lymphocytes from the original stem cell donor are infused, after the transplant, to augment an anti-tumor immune response or ensure that the donor stem cells remain engrafted. [1] [2] These donated white blood cells contain cells of the immune system that can recognize and destroy cancer cells.
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