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The most common side effects include thromboembolic events (problems due to the formation of blood clots in the blood vessels), diarrhea, and hypertension (high blood pressure). [ 3 ] Vadadustat was approved for medical use in the European Union in April 2023, [ 3 ] and in the United States in March 2024.
Side effects may include heart problems if given too quickly by injection into a vein. [4] By mouth it can result in abdominal pain, peptic ulcer disease, or gastrointestinal bleeding. [4] Greater care is recommended in those with kidney problems. [2]
Kidney toxicity [5] associated with kidney failure; associated with development of cancer, particularly of the urinary tract, known carcinogen [8] [9] Atractylate Atractylis gummifera: Liver damage, [3] nausea, vomiting, epigastric and abdominal pain, diarrhoea, anxiety, headache and convulsions, often followed by coma [10]
Colon cleansing supplements may lead to dehydration, Hussan says. If you have a pre-existing kidney condition, cleansing your colon may cause an electrolyte imbalance in the bloodstream, he adds ...
Still, more serious risks may include pancreatitis, gallbladder issues, kidney failure and an increased risk of thyroid tumors, though these risks are relatively rare and seen in folks with a ...
Roxadustat is reported to increase VEGF, a signal protein that can activate tumor growth [8] and also is considered to cause pulmonary hypertension. [9] In phase 3 trial conducted at 29 sites in China, roxadustat treatment was found to cause hyperkalemia, i.e., increase in serum potassium, and metabolic acidosis in patients.