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[21] [22] [23] Risk factors for coronary heart disease included abnormal lipid levels in the blood, diabetes mellitus, high blood pressure, and smoking. [22] They recommended selective use of low-to-moderate doses statins in the same adults who have a calculated 10-year cardiovascular disease event risk of 7.5–10% or greater. [ 22 ]
Antihypertensive agents comprise multiple classes of compounds that are intended to manage hypertension (high blood pressure). Antihypertensive therapy aims to maintain a blood pressure goal of <140/90 mmHg in all patients, as well as to prevent the progression or recurrence of cardiovascular diseases (CVD) in hypertensive patients with established CVD. [2]
This medication may also be prescribed to people with overweight who have a weight-related condition like type 2 diabetes, high blood pressure (hypertension), or dyslipidemia (high cholesterol or ...
It decreases LDL by 15–30% and raises HDL by 3–5%, with little effect on triglycerides, but can cause a slight increase. Bile acid sequestrants may cause gastrointestinal problems and may also reduce the absorption of other drugs and vitamins from the gut. Ezetimibe is a selective inhibitor of dietary cholesterol absorption.
One of the main differences between the type 1 and type 2 statins is the replacement of the butyryl group of type 1 statins by the fluorophenyl group of type 2 statins. This group is responsible for additional polar interactions that causes tighter binding to the HMGR enzyme. Statins that belong to this group are: [9] Fluvastatin (Figure 3 ...
The pill in the study, which involved the participation of 6,800 rural villagers aged 50 to 75 in Iran, contained a cholesterol-lowering statin, two blood-pressure drugs and a low-dose aspirin. [14] [15] Certain "cardiovascular polypills" are currently available in India and have been extensively studied there (see Polycap and PolyIran, for ...
Blood pressure medication reduces cardiovascular disease in people at risk, [115] irrespective of age, [157] the baseline level of cardiovascular risk, [158] or baseline blood pressure. [159] The commonly-used drug regimens have similar efficacy in reducing the risk of all major cardiovascular events, although there may be differences between ...
Diet has an effect on blood cholesterol, but the size of this effect varies between individuals. [19] [20] A diet high in sugar or saturated fats increases total cholesterol and LDL. [21] Trans fats have been shown to reduce levels of high-density lipoprotein while increasing levels of LDL. [22]