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For this reason Japan ordered 15 million syringes at the beginning of 2021 and deliveries started within a month. [3] Hindustan Syringes & Medical Devices was established in 1957 [4] and is a family run business. In 1995 new machines were required for an increase in production and so private capital was needed.
Automatic syringes are known since the 1910s, [2] and many spring-loaded devices with needle protectors were patented in the first half of the 20th century, [3] but it was not until 1970s when they became economically feasible to mass-produce (simple syrettes were used instead before).
Many insulin analogs and GLP-1 agonists for diabetes treatment are available as injector pens. [2] As with insulin vials, some insulin pens are made with higher concentrations including U-200, U-300, and U-500. Different concentration insulin products may not have the same pharmacokinetic properties as other strengths. [10]
The dilution of insulin is such that 1 mL of insulin fluid has 100 standard "units" of insulin. [6] A typical insulin vial may contain 10 mL, for 1000 units. Insulin syringes are made specifically for a patient to inject themselves, and have features to assist this purpose when compared to a syringe for use by a healthcare professional:
The annual cost of insulin for people with type 1 diabetes in the US almost doubled from $2,900 to $5,700 over the period from 2012 to 2016. [269] Renewed attention was brought to Eli Lilly's pricing of insulin in November 2022, after a verified Twitter account impersonating Eli Lilly posted on Twitter that insulin would now be free.
Insulin glargine differs from human insulin by replacing asparagine with glycine in position 21 of the A-chain and by carboxy-terminal extension of B-chain by 2 arginine residues. The arginine amino acids shift the isoelectric point from a pH of 5.4 to 6.7, making the molecule more soluble at an acidic pH and less soluble at physiological pH.
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