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There are two identified mechanisms behind hair cell regeneration; the first is that supporting cells re-enter the mitotic cycle to create and differentiate new hair cells. [8] The second process is the direct transdifferentiation of supporting cells into hair cells, which occurs via a change in the gene expression profile of supporting cells. [8]
The cell cycle inhibitor p27kip1 has also been found to encourage regrowth of cochlear hair cells in mice following genetic deletion or knock down with siRNA targeting p27. [36] [37] Research on hair cell regeneration may bring us closer to clinical treatment for human hearing loss caused by hair cell damage or death.
[5] [6] Furthermore, Hensen's cells are also able to regenerate the damaged hair cells in some vertebrates; they undergo phagocytosis to eject the dead or injured hair cells, and reproduce both new hair cells and supporting cells into the cell cycle. One of the reasons is that the supporting cells are differentiated by the embryonic hair cells ...
The hair cells are arranged in four rows in the organ of Corti along the entire length of the cochlear coil. Three rows consist of outer hair cells (OHCs) and one row consists of inner hair cells (IHCs). The inner hair cells provide the main neural output of the cochlea.
The organ of Corti is located in the scala media of the cochlea of the inner ear between the vestibular duct and the tympanic duct and is composed of mechanosensory cells, known as hair cells. [2] Strategically positioned on the basilar membrane of the organ of Corti are three rows of outer hair cells (OHCs) and one row of inner hair cells ...
In the semicircular canals, the hair cells are found in the crista ampullaris, and the stereocilia protrude into the ampullary cupula. Here, the stereocilia are all oriented in the same direction. In the otoliths, the hair cells are topped by small, calcium carbonate crystals called otoconia. Unlike the semicircular ducts, the kinocilia of hair ...
The hair cells function as a transducer, converting the mechanical movement of the basilar membrane into electrical voltage, in a process requiring ATP from the stria vascularis as an energy source. The depolarized hair cell releases neurotransmitters across a synapse to primary auditory neurons of the spiral ganglion .
The spiral (cochlear) ganglion is a group of neuron cell bodies in the modiolus, the conical central axis of the cochlea. These bipolar neurons innervate the hair cells of the organ of Corti . They project their axons to the ventral and dorsal cochlear nuclei as the cochlear nerve , a branch of the vestibulocochlear nerve (CN VIII).