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Refractory coeliac disease should not be confused with the persistence of symptoms despite gluten withdrawal [114] caused by transient conditions derived from the intestinal damage, [111] [112] [115] which generally revert or improve several months after starting a gluten-free diet, [116] [117] such as small intestinal bacterial overgrowth ...
The degree of gluten cross contamination tolerated by people with non-celiac gluten sensitivity is not clear but there is some evidence that they can present with symptoms even after consumption of small amounts. [37] Sporadic accidental contaminations with gluten can reactivate movement disorders associated with non-celiac gluten sensitivity. [72]
A recently proposed criterion to non-coeliac gluten sensitivity diagnosis concludes that an improvement of gastrointestinal symptoms and extra-intestinal manifestations higher than 50% with a gluten-free diet, assessed through a rating scale, may confirm the clinical diagnosis of non-coeliac gluten sensitivity. Nevertheless, this rating scale ...
Gluten-sensitive enteropathy–associated conditions are comorbidities or complications of gluten-related gastrointestinal distress (that is, gluten-sensitive enteropathy or GSE). GSE has key symptoms typically restricted to the bowel and associated tissues; however, there are a wide variety of associated conditions.
[10] [21] Unlike EATL, it often occurs in celiac disease patients who, while otherwise well-maintained on a gluten-free diet, have vague gastrointestinal symptoms such as fatigue, malaise, and weight loss. [21] However, it can cause severe symptoms such as bowel obstruction [22] and intestinal bleeding. [23]
Children with celiac disease often present with symptoms like abdominal distension or bloating, as well as failure to thrive, anemia and diarrhea. Because these symptoms are vague and can be related to many other conditions or food allergies, celiac disease can be difficult to diagnose unless there is a family history to help as a cue.
Non-celiac gluten sensitivity (NCGS) is described as a condition of multiple symptoms that improves when switching to a gluten-free diet, after celiac disease and wheat allergy are excluded. [ 64 ] [ 65 ] Recognized since 2010, [ 66 ] [ 67 ] it is included among gluten-related disorders . [ 66 ]
Duodenal lymphocytosis, sometimes called lymphocytic duodenitis, lymphocytic duodenosis, or duodenal intraepithelial lymphocytosis, is a condition where an increased number of intra-epithelial lymphocytes is seen in biopsies of the duodenal mucosa when these are examined microscopically.