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In a healthy sinoatrial node (SAN, a complex tissue within the right atrium containing pacemaker cells that normally determine the intrinsic firing rate for the entire heart [3] [4]), the pacemaker potential is the main determinant of the heart rate. Because the pacemaker potential represents the non-contracting time between heart beats , it is ...
In pacemaker cells (e.g. sinoatrial node cells), however, the increase in membrane voltage is mainly due to activation of L-type calcium channels. These channels are also activated by an increase in voltage, however this time it is either due to the pacemaker potential (phase 4) or an oncoming action potential. The L-type calcium channels are ...
The action potential generated by the SA node passes down the electrical conduction system of the heart, and depolarizes the other potential pacemaker cells (AV node) to initiate action potentials before these other cells have had a chance to generate their own spontaneous action potential, thus they contract and propagate electrical impulses ...
Once the pacemaker potential reaches a set value, the threshold potential, it produces an action potential. [2] Other cells within the heart (including the Purkinje fibers [11] and atrioventricular node) can also initiate action potentials; however, they do so at a slower rate and therefore, if the SA node is functioning properly, its action ...
A slow heart rate of 60 or less beats per minute is defined as bradycardia. A fast heart rate of more than 100 beats per minute is defined as tachycardia. An arrhythmia is defined as one that is not physiological such as the lowered heart rate that a trained athlete may naturally have developed; the resting heart rates may be less than 60 bpm.
Other potential causes include: Heart tissue scarring from a previous heart attack or other cause. Cardiomyopathy. ... A pacemaker. Implantable cardioverter defibrillator (a device that shocks ...
“The idea behind the pacemaker is to help stimulate the heart in a more regular rhythm,” Dr. Sadiya Khan, a professor of cardiovascular epidemiology at Northwestern Feinberg School of Medicine ...
The pacemaker current (I f, or I Kf, also called funny current) is an electric current in the heart that flows through the HCN channel or pacemaker channel. Such channels are important parts of the electrical conduction system of the heart and form a component of the natural pacemaker .