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Digoxin (better known as Digitalis), sold under the brand name Lanoxin among others, is a medication used to treat various heart conditions. [4] Most frequently it is used for atrial fibrillation, atrial flutter, and heart failure. [4] Digoxin is one of the oldest medications used in the field of cardiology.
Oleandrin is a cardiac glycoside found in the poisonous plant oleander (Nerium oleander L.). [1] As a main phytochemical of oleander, oleandrin is associated with the toxicity of oleander sap, and has similar properties to digoxin.
Digoxigenin (DIG) is a steroid found exclusively in the flowers and leaves of the plants Digitalis purpurea, Digitalis orientalis and Digitalis lanata (foxgloves), where it is attached to sugars, to form the glycosides (e.g. digoxin, lanatoside C). [2]
Unlike digoxin, which is eliminated from the body via the kidneys, it is eliminated via the liver, and so can be used in patients with poor or erratic kidney function. While several controlled trials have shown digoxin to be effective in a proportion of patients treated for heart failure, the evidence base for digitoxin is not as strong ...
Other traditional uses include as an expectorant, astringent, and to treat bronchitis. [83] The essential oil of the plant has been used for centuries as a general tonic for colds and coughs, and to relieve congestion of the mucous membranes. Glycyrrhiza glabra: Licorice root: Purported uses include stomach ulcers, bronchitis, and sore throat. [84]
Digoxin is widely used in the treatment of various heart conditions. A typical protocol to isolate a pure chemical agent from natural origin is bioassay-guided fractionation , meaning step-by-step separation of extracted components based on differences in their physicochemical properties, and assessing the biological activity , followed by next ...
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Examples include digoxin, digitoxin, diosgenin, and guggulsterone, as well as phytosterols like β-sitosterol and other phytoestrogens like isoflavones. [ 1 ] Industrial use