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Vitamin B 12, also known as cobalamin, is a water-soluble vitamin involved in metabolism. [2] It is one of eight B vitamins.It is required by animals, which use it as a cofactor in DNA synthesis, and in both fatty acid and amino acid metabolism. [3]
B12 is found in a wide array of animal-based foods, as it's produced by a gut bacteria that is then accumulated in the muscle tissue of most herbivorous animals, including fish, cows, chickens ...
Serum vitamin B 12 is a medical laboratory test that measure vitamin B 12 only in the blood binding to both transcobalamins. [1] Most of the time, 80–94% of vitamin B 12 in the blood binds to haptocorrin, while only 6–20% is binds to transcobalamin ll. [2] Only transcobalamin ll is "active" and can be used by the body. [1]
Vitamin B 12 cannot be produced by the human body, and must be obtained from the diet. [2] The body normally gets enough vitamin B 12 from the consumption of foods from animal sources. [2] Inadequate dietary intake of animal products such as eggs, meat, milk, fish, fowl (and some types of edible algae) can result in a deficiency state. [134]
Another study of over 600 young adults and children looked at the link between vitamin B12 levels and body mass index (BMI), with lower B12 levels resulting in higher body weight.
“The combination of body and cognitive changes is a major clue that a treatable cause such as B12 deficiency could be the issue,” he says. How vitamin B12 deficiency is detected
Hydroxocobalamin, or another form of vitamin B 12, are required for the body to make DNA. [7] Hydroxocobalamin was first isolated in 1949. [9] It is on the World Health Organization's List of Essential Medicines. [10] Hydroxocobalamin is available as a generic medication. [2] Commercially it is made using one of a number of types of bacteria. [11]
Adenosylcobalamin (AdoCbl), also known as coenzyme B 12, cobamamide, and dibencozide, is one of the biologically active forms of vitamin B 12. [1] Schematic diagram of the propionate metabolic pathway.