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Casgevy works by editing the DNA in a patient’s stem cells — which are responsible for making the body’s blood cells — so that they no longer produce sickle-shaped cells.
Exagamglogene autotemcel, sold under the brand name Casgevy, is a gene therapy used for the treatment of sickle cell disease [3] [5] and transfusion-dependent beta thalassemia. [3] It was developed by Vertex Pharmaceuticals and CRISPR Therapeutics .
Lovotibeglogene autotemcel, sold under the brand name Lyfgenia, is a lentiviral gene therapy used for the treatment of sickle cell disease. [1] [3] [4] [5]The most common side effects include stomatitis (mouth sores of the lips, mouth, and throat), low levels of platelets, white blood cells, and red blood cells, and febrile neutropenia (fever and low white blood cell count), consistent with ...
[173] [174] In December 2023, the US Food and Drug Administration (FDA) approved the first cell-based gene therapies for treating sickle cell disease, Casgevy and Lyfgenia. Casgevy is the first FDA approved gene therapy to use the CRISPR-Cas9 technology and works by modifying a patient's hematopoietic stem cells. [175]
The categories of IQ vary between IQ test publishers as the category labels for IQ score ranges are specific to each brand of test. The test publishers do not have a uniform practice of labeling IQ score ranges, nor do they have a consistent practice of dividing up IQ score ranges into categories of the same size or with the same boundary ...
Hemoglobin electrophoresis is a test that can detect different types of hemoglobin. Hemoglobin is extracted from the red cells, then introduced into a porous gel and subjected to an electrical field. Hemoglobin is extracted from the red cells, then introduced into a porous gel and subjected to an electrical field.
The test is currently in its second edition, published in 2015. [2] Both editions are suitable for evaluation of intellectual giftedness, [3] and high scores are accepted as qualifying evidence for high IQ societies such as Intertel (min. IQ ≥ 135) and American Mensa (min. IQ ≥ 130). [4] [5]
[1] [2] It was influenced by the theory of g factor. [1] [2] Vernon puts emphasis on the g factor in all the mental abilities. He extracted the g factor from an ability test, then found that those remaining content [clarification needed] could be divided into two separate parts. He named those two orthogonal group factors as verbal-educational ...
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