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The estimated prevalence of PML in MS is 1.5 cases per thousand natalizumab users. [8] Around 20% of MS patients with PML die, and most of the rest are very disabled. [8] One case study describes an MS patient who, during a 4-year course of dimethyl fumarate, developed PML and died. [9] Fingolimod (Gilenya) was approved in 2010 by the FDA for ...
Acute promyelocytic leukemia is characterized by a chromosomal translocation involving the retinoic acid receptor alpha (RARA) gene on chromosome 17. [3] In 95% of cases of APL, the RARA gene on chromosome 17 is involved in a reciprocal translocation with the promyelocytic leukemia gene (PML) on chromosome 15, a translocation denoted as t(15;17)(q22;q21). [3]
Posterior reversible encephalopathy syndrome (PRES), also known as reversible posterior leukoencephalopathy syndrome (RPLS), is a rare condition in which parts of the brain are affected by swelling, usually as a result of an underlying cause.
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Promyelocytic leukemia protein (PML) (also known as MYL, RNF71, PP8675 or TRIM19 [5]) is the protein product of the PML gene. PML protein is a tumor suppressor protein required for the assembly of a number of nuclear structures, called PML-nuclear bodies, which form amongst the chromatin [ 5 ] of the cell nucleus.
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A migraine attack can be a debilitating condition. But a headache is just one part. There are other subtle warning symptoms to watch out for, neurologists say.
Hypoglycemic encephalopathy is often seen in diabetics as a result to accidental overdose with the long-acting sulfonylurea drug group. [12] Brain regions affected by toxic leukoencephalopathy have been seen to be affected by this disease as well; however, hypoglycaemic encephalopathy has been known to involve both white and grey matter ...