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In orthopaedic medicine, a bone graft can be sourced from a patient's own bone in order to fill space and produce an osteogenic response in a bone defect. However, due to the donor-site morbidity associated with autograft, other methods such as bone allograft and bone morphogenetic proteins and synthetic graft materials are often used as alternatives.
Tissue engineering, like 3D bioprinting, is an emerging field of study about constructing tissue-like structures by precisely layering cells, growth factors and biomaterials. [33] This field could revolutionize tissue transplants by synthesizing personalized grafts for enhanced integration without immune rejection and reducing reliance on ...
Graft-versus-host disease (GvHD) is an inflammatory disease that is unique to allogeneic transplantation. It is an attack by the "new" bone marrow's immune cells against the recipient's tissues. This can occur even if the donor and recipient are HLA-identical because the immune system can still recognize other differences between their tissues.
With the immune system incapacitated, a critical component of the known tumor microenvironment interaction is foregone, preventing immunotherapies and anti-cancer agents that target the immune system components from being studied in PDX models. Researchers are beginning to explore the use of humanized-xenograft models to enable immune studies.
Behind the large stem cell cosmetic therapy market size of South Korea, non-specialists practice without a license in some clinics. According to the National Statistical Office , the number of plastic surgeons was 1,924 in 2018, and the Korean Plastic Surgery Association estimates that non-specialists in cosmetic surgery will be about 10 times ...
Bone marrow transplant can replace the transplant recipient's immune system with the donor's, and the recipient accepts the new organ without rejection. The marrow's hematopoietic stem cells —the reservoir of stem cells replenishing exhausted blood cells including white blood cells forming the immune system—must be of the individual who ...
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