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Clofazimine was originally intended as an anti-tuberculosis drug but proved ineffective. In 1959, a researcher named Y. T. Chang identified its effectiveness against leprosy. After clinical trials in Nigeria and elsewhere during the 1960s, Swiss pharmaceutical company Novartis launched the product in 1969 under the brand name Lamprene.
Leprosy has historically been associated with social stigma, which continues to be a barrier to self-reporting and early treatment. [4] Leprosy is classified as a neglected tropical disease. [21] World Leprosy Day was started in 1954 to draw awareness to those affected by leprosy. [22] [4] The study of leprosy and its treatment is known as ...
Current recommendations for the treatment of leprosy suggest multidrug regimens rather than monotherapy because such a regimen has proven to be more effective, delays the emergence of resistance, prevents relapse, and shortens the duration of therapy. Established agents used in the treatment of leprosy are dapsone, clofazimine, and rifampicin ...
In 1957 Price was appointed to the Colonial Medical Service of the then Eastern Region, Nigeria later Biafra. [17] He worked in orthopaedic surgery on the rehabilitation of leprosy patients. He was based first at Uzuakoli leprosarium and Research centre, [18] where Frank Davey [19] was working on the new Dapsone treatment of leprosy.
Mycobacterium leprae (also known as the leprosy bacillus or Hansen's bacillus) is one [a] of the two species of bacteria that cause Hansen's disease (leprosy), [1] a chronic but curable infectious disease that damages the peripheral nerves and targets the skin, eyes, nose, and muscles.
In 2020, 159 new leprosy cases were reported in the U.S., and Florida was among the top states reporting cases, according to a research letter in the journal Emerging Infectious Diseases ...
They concluded that a single dose of a combination of rifampicin, ofloxacin and minocycline is an acceptable and cost-effective alternative regimen for the treatment of single-lesion paucibacillary leprosy and the duration of the standard regimen for multibacillary leprosy could be shortened to 12 months.
The Leprosy Notes of 1928 and 1929 as well as all Leprosy Review issues from 1930 to 2001 are freely available online thanks to the Full Text Leprosy Project, an initiative of the Lauro de Souza Lima Institute of Secretary of Health of São Paulo, in cooperation with the Latin American and Caribbean Center on Health Sciences Information and The ...