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Polypyrimidine tract-binding protein, also known as PTB or hnRNP I, is an RNA-binding protein. PTB functions mainly as a splicing regulator, although it is also involved in alternative 3' end processing, mRNA stability and RNA localization. [ 1 ]
The PTB domains facilitate interaction with the activated tyrosine-phosphorylated insulin receptor. The PTB domain is situated towards the N terminus . Two arginines in this domain are responsible for hydrogen bonding phosphotyrosine residues on an Ac -LYASSNPApY- NH2 peptide in the juxtamembrane region of the insulin receptor.
Advanced Placement (AP) Biology (also known as AP Bio) is an Advanced Placement biology course and exam offered by the College Board in the United States. For the 2012–2013 school year, the College Board unveiled a new curriculum with a greater focus on "scientific practices". [1]
Only 43.6% of adults (older than 18) have received a TDaP shot in the last 10 years. [20] The CDC aimed to increase vaccination rate among 2-year-olds from 80.4% to 90.0% [ 21 ] The World Health Organization (WHO) estimated that 89% of people globally had received at least one dose of DTP vaccine and 84% had received three doses of the vaccine ...
In 2010, 8.8 million new cases of tuberculosis were diagnosed, and 1.20–1.45 million deaths occurred (most of these occurring in developing countries). [78] [171] Of these, about 0.35 million occur in those also infected with HIV. [172] In 2018, tuberculosis was the leading cause of death worldwide from a single infectious agent. [1]