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Corticotropin-releasing hormone (CRH) (also known as corticotropin-releasing factor (CRF) or corticoliberin; corticotropin may also be spelled corticotrophin) is a peptide hormone involved in stress responses. It is a releasing hormone that belongs to corticotropin-releasing factor family. In humans, it is encoded by the CRH gene. [5]
Urocortin acts in vitro to stimulate the secretion of adrenocorticotropic hormone. Urotensin is found in the teleost caudal neurosecretory system and may play a role in osmoregulation and as a corticotropin-releasing factor. Urotensin-I is released from the urophysis of fish, and produces ACTH and subsequent cortisol release in vivo.
Adrenocorticotropic hormone (ACTH; also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced by and secreted by the anterior pituitary gland. [1] It is also used as a medication and diagnostic agent .
Corticotropin-releasing hormone receptors (CRHRs), also known as corticotropin-releasing factor receptors (CRFRs) are a G protein-coupled receptor family that binds corticotropin-releasing hormone (CRH). [1] There are two receptors in the family, designated as type 1 and 2, each encoded by a separate gene (CRHR1 and CRHR2 respectively).
The release of cortisol is controlled by the hypothalamus of a brain. Secretion of corticotropin-releasing hormone by the hypothalamus triggers cells in its neighboring anterior pituitary to secrete adrenocorticotropic hormone (ACTH) into the vascular system, through which blood carries it to the adrenal cortex. [1]
The N-terminal signal peptides of corticotropin-releasing hormone receptor 1 and CRHR2 beta are cleaved off in the endoplasmic reticulum to yield the mature receptors. In contrast, CRHR2 alpha contains a unique pseudo signal peptide that is not removed from the mature receptor.
Corticotropin-releasing hormone binding protein (CRH-BP) binds corticotropin-releasing hormone and several related peptide hormones (urocortin 1, urotensin 1, and sauvagine). [1] It is an ancient, highly conserved protein whose origin predates the divergence of protostomes and deuterostomes .
Antalarmin (CP-156,181) is a drug that acts as a CRH1 antagonist. Corticotropin-releasing hormone (CRH), also known as Corticotropin-releasing factor, is an endogenous peptide hormone released in response to various triggers such as chronic stress and drug addiction.