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End organ damage is severe impairment of major body organs due to systemic disease. Commonly this is referred to in diabetes , high blood pressure , or states of low blood pressure or low blood volume. [ 1 ]
Neuromuscular junction (motor end-organ) Lamellar corpuscle (Pacinian corpuscle end-organ) The ultimately affected organ in a chain of events, such as a disease process (pathophysiology) or a drug's mechanism of action (sometimes called a target organ in this sense) End organ damage, disease of such organs Ambulatory blood pressure § Target ...
The heart and lungs are vital organs for human life due to their ability to properly oxygenate human blood (lungs) and distribute this blood to all vital organs (heart). Hence, failure of the heart to pump blood or the lungs to obtain oxygen can lead to a cardiopulmonary death where the heart stops pumping and there is no pulse.
Once Shiga toxin enters the circulation it can travel throughout the body and cause the wide array of end organ damage and the multitude of symptoms seen with HUS. Shiga toxin gains entry to cells by binding to globotriaosylceramide (Gb3) which is a globoside found on cell membranes, it is found throughout the body including the surface of the ...
Pathophysiology (or physiopathology) is a branch of study, at the intersection of pathology and physiology, concerning disordered physiological processes that cause, result from, or are otherwise associated with a disease or injury.
Pre-eclampsia is a multi-system disorder specific to pregnancy, characterized by the new onset of high blood pressure and often a significant amount of protein in the urine or by the new onset of high blood pressure along with significant end-organ damage, with or without the proteinuria.
At present, there is no drug or device that can reverse organ failure that has been judged by the health care team to be medically and/or surgically irreversible (organ function can recover, at least to a degree, in patients whose organs are very dysfunctional, where the patient has not died; [citation needed] and some organs, like the liver or ...
Today, where a definition of the moment of death is required, doctors and coroners usually turn to "brain death" or "biological death" to define a person as being dead; [27] people are considered dead when the electrical activity in their brain ceases. [28] It is presumed that an end of electrical activity indicates the end of consciousness. [29]