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SMN1 and SMN2 are part of a 500 kbp inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region.
Original file (931 × 720 pixels, file size: 4.99 MB, MIME type: application/pdf) This is a file from the Wikimedia Commons . Information from its description page there is shown below.
NEC's 64 kb SRAM memory chip in 1981. [47] Intel 80286 CPU launched in 1982. The Amiga Advanced Graphics Architecture (initially sold in 1992) included chips such as Alice that were manufactured using a 1.5 μm CMOS process. [99]
The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. The nucleotide substitution in SMN2 results in around 80-90% of its transcripts to be a truncated, unstable protein of no biological function (Δ7SMN) and only 10-20% of its transcripts being full-length ...
A transcribed enhancer RNA (eRNA) interacting with the complex of Mediator proteins (see Figure), especially Mediator subunit 12 , appears to be essential in forming the chromosome loop that brings the enhancer into close association with the promoter of the target gene of the enhancer in the case of five genes studied by Lai et al. [15] [16 ...
[6] [7] [8] Nominally, the Hercules card provides a horizontal scanning frequency of 18.425 ± 0.500 kHz and 50 Hz vertical. [9] It runs at two slightly different sets of frequencies depending on whether in text or graphics mode, providing a different vertical refresh rate and a different aspect ratio via a different pixel clock and number of ...