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Medically unexplained physical symptoms (MUPS or MUS) are symptoms for which a treating physician or other healthcare providers have found no medical cause, or whose cause remains contested. [1] In its strictest sense, the term simply means that the cause for the symptoms is unknown or disputed—there is no scientific consensus .
The main symptom is "post-exertional neuroimmune exhaustion" (PENE), which encompasses fatigability, symptoms worsening after exertion, exhaustion after exertion, a prolonged recovery from activity, and reduction of activities due to symptoms. The ICC definition describes severity levels: Mild ME is described as roughly a 50% in functioning ...
A range of other symptoms commonly result from CFS including headaches, muscle and joint pain and low-grade fever. [14] ICF requires: only one symptom: chronic fatigue; does not need a significant reduction in activities: some people are able to push through the fatigue to continue activities; is only diagnosed if CFS symptoms are not met. [6]
Functional somatic syndrome (FSS) is any of a group of chronic diagnoses with no identifiable organic cause.This term was coined by Hemanth Samkumar. [citation needed] It encompasses disorders such as fibromyalgia, chronic widespread pain, temporomandibular disorder, irritable bowel syndrome, [1] lower back pain, tension headache, atypical face pain, non-cardiac chest pain, insomnia ...
Some medical conditions have symptoms similar to ME/CFS. Diagnosis often involves clinical evaluation, testing, and specialist referrals to identify the correct condition. During the time other possible diagnoses are explored, advice can be given on symptom management to help prevent the condition from getting worse.
In a 25 March 2021 interview, Marrero said that initial symptoms are often nonspecific, making a diagnosis challenging. He listed symptoms such as "behavioral changes, sleep disturbances, unexplained pain, visual hallucinations, coordination problems, unexplained hair loss, involuntary muscle twitching, formication (a sensation that feels like small insects crawling under the skin), ataxia ...
[5] [15] Recovery is often preceded by a change in the character of the symptom from constant to intermittent. [15] No clinical factors predicting recovery have been noted. [15] If there is an identifiable cause for the burning sensation, then psychologic dysfunctions such as anxiety and depression often disappear if the symptom is successfully ...
Some investigations suggest people can recover; the natural history of the illnesses implies that around 50% to 75% of patients with medically unexplained symptoms improve, whereas 10% to 30% deteriorate. Fewer physical symptoms and better baseline functioning are stronger prognostic indicators. A strong, positive relationship between the ...