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6 month mortality is >=60% with fluconazole-based therapy and 40% with amphotericin-based therapy in research studies in low and middle income countries. [27] Anthrax, gastrointestinal: Bacterial Unvaccinated and untreated > 50% [7]: 27 Tetanus, Generalized Bacterial Unvaccinated and untreated 50% CFR drops to [10–20]% with effective treatment.
The mortality rate from sepsis, especially if it is not treated rapidly with the needed medications in a hospital, is approximately 40% in adults and 25% in children. It is significantly greater when sepsis is left untreated for more than seven days. [36]
In a small study of 26 decedents, [better source needed] the pandemized COVID-19 and infection-related disease were "major contributors" to patients' death. [12] Such deaths are sometimes evaluated via excess deaths per capita – the COVID-19 pandemic deaths between January 1, 2020, and December 31, 2021, are estimated to be ~18.2 million ...
Left untreated, bubonic plague will have a CFR of up to 60%. [21]: 57 With antibiotic treatment, the CFR for bubonic plague is 17%, pneumonic 29% and septicaemic 45%. [22] [23] Active tuberculosis, the infection with the highest mortality rate, has a CFR of 43% in the absence of HIV. [24] [25]
Mortality in MODS from septic shock (which itself has a high mortality of 25–50%), and from multiple traumas, especially if not rapidly treated, appear to be especially severe. If more than one organ system is affected, the mortality rate is still higher, and this is especially the case when five or more systems or organs are affected.
Due to it rarely being reported as a primary diagnosis (often being a complication of cancer or other illness), the incidence, mortality, and morbidity rates of sepsis are likely underestimated. [30] A study of U.S. states found approximately 651 hospital stays per 100,000 population with a sepsis diagnosis in 2010. [ 110 ]
In September 2020, the outcomes of 1,035 COVID-19 patients supported with ECMO from 213 experienced centers in 36 different countries were published in The Lancet, and demonstrated 38% mortality, which is similar to many other respiratory diseases treated with ECMO.
For the Netherlands, based on overall excess mortality, an estimated 20,000 people died from COVID-19 in 2020, [10] while only the death of 11,525 identified COVID-19 cases was registered. [9] The official count of COVID-19 deaths as of December 2021 is slightly more than 5.4 million, according to World Health Organization's report in May 2022 ...